Brain Degeneration and Therapeutics Group

bdtg

Group Members

Group Leader

Dr. Gurmeet Kaur A/P Surindar Singh – Faculty of Pharmacy

Members

Professor Dato’ Dr. Abu Bakar Abdul Majeed– Faculty of Pharmacy

Dr. Richard Muhammad Johari James– Faculty of Pharmacy

Dr. Mahenderan A/L Appukutty- Faculty of Sports Science & Recreation

Dr. Rakesh Kumar Mishra– Faculty of Pharmacy

 

Laboratories

  • Brain Research Laboratory 1 (Animal Physiology)
  • Brain Research Laboratory 2 (Molecular Biology)
  • Behavioral and Experimental Therapeutic Laboratory

Postgraduate Students

No

Postgraduate Students

Degree

Year Enrolled

Year End

1

Rosa Elisabeth Pereira

PhD

2005

2008

2

Nadeem Irfan

PhD

2006

2009

3

Wan Zie

PhD

2005

2010

4

Siti Hadijah

PhD

2006

2011

5.

Richard Muhammad Bin Johari James

PhD

2007

2013

6.

Tommy Julianto

PhD

2005

On-going

7.

Mohd. Nazif B. Samat@Derawi

PhD

2006

On-going

8.

Salizatul Ilyana Binti Ibrahim

PhD

2007

On-going

9.

Mohammed Rajihuzzaman

PhD

2010

On-going

10.

Shantakumari Rajan

PhD

2010

On-going

11.

Ainon Zahariah Samsudin

PhD

2011

On-going

12.

Ezlina Uzir

MSc

2005

2009

13.

Roskhatijah

MSc

2007

2010

14.

Salwati

MSc

2007

2010

15.

Hana

MSc

2007

2011

16.

Liza

MSc

2008

2011

17.

Meor Mohd Redzuan

MSc

2008

2011

18.

Elly Ezlinda Abdul Hisam

MSc

2008

2012

19.

Aliya Ahmad

MSc

2010

2012

20.

Mohd Maaruf Bin Hj. Abdul Malik

MSc

2010

On-going

21.

Marsita Binti Abd Razak

MSc

2012

On-going

22.

Siti Norshazwani Wahab

MSc

2011

On-going

23.

Siti Murnirah Jaafar

MSc

2011

On-going

24.

Nur Syamimi Mohd Azahan

MSc

2013

On-going

25.

Muhamad Khalil Bin Jamian

MSc

2013

On-going

26.

Suraya Binti Mohd Noh

MSc

2014

On-going

27.

Nurol Eizzatie Binti Yaacob

MSc

2014

On-going

On-going Research Grants

 

Research Project

Source

Begin Year

End Year

 

Principal Investigator

     

1.

Ciproxifan, a Histamine H3 Antagonist as a Potential Therapeutic agent in Alzheimer’s Disease

E-Science (MOSTI)

2013

2015

2.

Mechanism of Ciproxifan Against Cholinergic Deficit-Induced Neuronal Plasticity Via Brain-Derived Neurotrophic Factor (Bdnf) Signaling Pathway Part 2

PSI (UiTM)

2013

2015

3.

Ciproxifan, a Histamine H3 Antagonist as a Potential Therapeutic Agent in Alzheimer's Disease Part 2

PSI (UiTM)

2013

2015

4.

Brain Degeneration and Therapeutics Group

REI (UiTM)

2013

2015

5.

Ciproxifan, a Histamine H3 Antagonist as a Potential Therapeutic Agent in Alzheimer's Disease Part 3

CIFI (UiTM)

2013

2015

6.

AD Blood Biomarkers and Pathway Analysis in the Human Subject: An Integrative-Omics Approach.

LRGS (MOHE)

2012

2016

7.

Vesicular Neurotransmitter Transporter: Bioenergetics and Regulation of D-Serine Transport

FRGS (MOHE)

2012

2015

8.

Neuroprotective Roles of Mahanimbine, a Carbazole Alkaloid from Murrraya koenigii Leaves

E-Science (MOSTI)

2012

2014

9.

Intranasal Route for Alzheimer’s Treatment Using Novel Biodegradable Polymeric Nanoparticles

ERGS (MOHE)

2012

2015

10.

Exercise and Probiotic on Scopolamine-Induced Memory Deficits in Experimental Animal Models

RIF (UiTM)

2012

2014

11.

Comparative Neuroprotective Activities of Total Isoflavone Extract from Soybean and Tempeh

DANA (UiTM)

2011

2013

12.

Neuroprotective Effect of Ciproxifan, a Histamine H3 Antagonist on High Fat Diet – Induced Cognitive Impairment.

DANA (UiTM)

2011

2013

 

Co-researcher

     

13.

VEGF Signaling Cascade Underlying Endophytic Peptides Orchestrated Anti-angiogenicity

FRGS (MOHE)

2013

2015

14.

Integrative Systematic Biology in Understanding the Cellular and Molecular Mechanisms of Locally Derived Feed Supplements for Poultry.

LRGS (MOHE)

2012

2016

15.

Novel and Smart pH-Sensitive 5-FU-Loaded Hydrogels for Targeted Drug Delivery Against Colon Cancer

RIF (UiTM)

2012

2014

16.

Potential anti-Alzheimer''s Activity of Brown Algae Metabolites

E-Science (MOSTI)

2012

2014

17.

Probiotics as a Neuroceutical for Alzheimer’s Disease

E-Science (MOSTI)

2012

2014

18.

Molecular Mechanisms for Improvement of Cognitive Parameters and Amelioration of ?-Amyloid Production Senescence-Accelerated Mice by Fraction 7 of P.minus.

FRGS (MOHE)

2012

2014

19.

Discerning Potential Neuroprotective from Virgin Coconut Oil on ?-Amyloid Induced SH-SY5Y Cell.

ERGS (MOHE)

2011

2013

Selected Publications (2012 – 2014)

  1. Ahmad,A., Ramasamy, K., Jaafar, S.M., Majeed, A.B.A., Vasudevan, M. Total isoflavones from soybean andtempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain. Food and Chemical Toxicology. 2014; 65: 120-128. (IF= 3.010)
  2. Vasudevan, M., Kalavathy, R., Aliya, A., Wahab, S.N., Jaafar, S.M., Teh, L.K., Salleh.M.Z., Abu B.A.M. Role of total alkaloidal extract from Murraya koenigii leaves on oxidative stress and cholinergic pathway in aged mice. Phytotherapy Research. 2013; 27: 46-53. (Impact Factor- 2.086).
  3. Vasudevan, M., Kalavathy, R., Abu B.A.M. Anti-Inflammatory, analgesic and anti-ulcerogenic effect of total alkaloidal extract from Murraya koenigii leaves in animal models. Food & Function 2013; 4: 557-567. (Impact Factor- 2.694).
  4. Saini, M., Kumar, P., Kumar, M. Ramasamy, K., Vasudevan, M., Rakesh, K. M., Majeed, A.B.A., Narasimhan, B. Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino) benzohydrazides. Arabian Journal of Chemistry2013. (Accepted) (Impact Factor- 2.266).
  5. Tahlan S., Kumar P., Ramasamy K., Vasudevan, M., Mishra R.K., Majeed A.B.A., Narasimhan B. Synthesis, antimicrobial, anticancer evaluation and QSAR studies of N -substituted benzylidene/2- hydroxynaphthalen-1-ylmethylene/3-phenylallylidene/5-oxopentylidene -4-(2-oxo-2-(4H-1,2,4-triazol-4-yl) ethylamino) benzohydrazides. Arabian Journal of Chemistry (2013) (Accepted) (Impact Factor- 2.266).
  6. Kumar, H., Kumar, P., Narasimhan, B., Kalavathy, R., Vasudevan, M., Mishra, R.K., Majeed, A.B.A., Synthesis,in vitro antimicrobial, anticancer and QSAR studies of N-(substituted phenyl)-2/4-(1H-indol-3-ylazo)-benzamides. Medicinal Chemistry Research 2013; 22: 1957-1971. (Impact Factor- 1.612).
  7. Aakash D. Narasimhan, B., Kalavathy, R., Vasudevan, M., Mishra, R.K., Majeed, A.B.A. Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 3-(5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl)-2-phenylquinazolin-4(3H)-one derivatives. Current Topics in Medicinal Chemistry 2013. (Accepted) (Impact Factor- 3.702).
  8. Kumar, M., Narasimhan, B., Kalavathy, R., Vasudevan, M., Mishra, R.K., Majeed, A.B.A. Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulphonamides. Arabian Journal of Chemistry 2013. (Accepted) (Impact Factor- 2.266).
  9. Kumar, P., Narasimhan, B., Ramasamy, K., Vasudevan, M., Mishra, R.K., Majeed, A. B. A., Clercq, E. D., N'-(4-((substituted imino)methyl)benzylidene)-substituted benzohydrazides: synthesis, antimicrobial, antiviral, anticancer evaluation, and QSAR studies. Monatshefte fur Chemie - Chemical Monthly 2013; 144: 825-849. (Impact Factor- 1.629).
  10. Mishra, R.K., Ramasamy, K., Ban, N.N., Majeed, A.B.A. (2013) Synthesis of poly[3-(methacryloylamino) propyl trimethylammonium chloride-co-methacrylic acid] copolymer hydrogels for controlled indomethacin delivery. Journal of Applied Polymer Science, 128 (5), 3365-3374 (Impact Factor = 1.395).
  11. Tripathy, S., Tripathy, M.K., Kar, P.K., Majeed, A.B.A. Solubility enhancement of gluten by   arginine : thermodynamics and solute solvent-interactions. Chemical Science Transactions 2013; 2: 208-212.
  12. Vasudevan, M., Kalavathy, R., Aliya, A., Milind, P., Syed A.A.S., Abu B.A.M. Protective effects of total alkaloidal extract from Murraya koenigii leaves on experimentally induced dementia. Food and Chemical Toxicology 2012; 50: 1036-1044 (Impact Factor-2.999).
  13. Sharma.S.K., Kumar, P., Narasimhan, B., Kalavathy, R., Vasudevan, M., Mishra, R.K., Majeed, A.B.A., Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. European Journal of Medicinal Chemistry 2012; 48: 16-25. (Impact Factor- 3.346).
  14. Sigroha, S., Kumar, P., Narasimhan, B., Kalavathy, R., Vasudevan, M., Mishra, R.K., Majeed, A.B.A., Design, synthesis, antimicrobial, anticancer evaluation and QSAR studies of 4-(substituted benzylidene-amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-ones. Medicinal Chemistry Research 2012; 21: 3863-3875. (Impact Factor- 1.612).
  15. Zakaria, Z.A., Abdul Hisam, E.E., Norhafizah, M., Rofiee, M,S,, Othman, F., Hasiah, A.H., Vasudevan, M. The Methanol Extract of Bauhinia purpurea Leaf Possessed Antiulcer Activity. Medical Principles and Practice, 2012; 21 (5): 476-482. (Impact Factor = 1.069).
  16. Mishra, R. K.,Ramasamy K., Majeed, A.B.A. pH-responsive Poly (DMAPMA-co-HEMA) based hydrogels for prolonged release of 5-Fluorouracil.Journal of Applied Polymer Science 2012; 126: E98-E107. (Impact Factor - 1.395).
  17. Mishra, R. K., Datt, M., Banthia, A.K., Majeed, A.B.A. Development of novel pectin based membranes as proton conducting material. International Journal of Plastics Technology 2012; 16: 80-88.
  18. Mishra, R. K., Banthia, A. K., Majeed, A.B.A. Pectin based formulations for biomedical applications: A review. Asian Journal of Pharmaceutical & Clinical Research 2012; 5 (4): 1. (Impact Factor = 0.7).
  19. Hazalin,N.A.M.N., Ramasamy, K., Lim, S.M., Cole, A.L.J., Majeed, A.B.A. Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest. Phytomedicine 2012; 19: 609–617. (Impact Factor = 3.26).
  20. Meor Mohd Affandi M.M.R., Julianto T., Majeed A.B.A. (2012). Enhanced Oral Bioavailability of Astaxanthin with Droplet Size Reduction. Food Science and Technology Research 2012; 18: 549-554. (Impact Factor = 0.57).
  21. Affandi, M.M.R. Meor Mohd., Abdullah, A., Julianto, T., Majeed A.B.A. Development of Simple High Performance Liquid Chromatographic Method for the Determination of Astaxanthin in Human Plasma. Food Science and Technology Research 2012; 18: 107-113. (Impact Factor = 0.57) 
  22. Suhaime Bin, I. H., Tripathy, M.K., Majeed, A.B.A. Environment sensitive polymers for ophthalmic drug delivery. International Journal of Pharma and Bio Sciences 2012; 3: 586-608. (Impact Factor = 0.47) 
  23. Appukutty, M., Radhakrishnan, A.K., Ramasamy, K., Ramasamy,R., Majeed, A.B.A., Ismail, M.N., Safii, N.K.,Poh, K.B., Chinna, K., Haleagrahara. N. Colostrum supplementation protects against exercise-induced oxidative stress in the skeletal muscle in mice. BMC Research Notes 5 (1), 649. (Impact Factor = 1.39)
  24. Usir,E., Lua, P.L., Majeed, A.B.A. Community Pharmacies in Malaysia Prevalence and Usage of Printed and Electronic Drug References and Patient Medication Records in Community Pharmacies in Malaysia. Journal of Pharmacy Practice published online 2012; 2.

Selected Awards (2012 – 2013)

  1. Best poster presentation award (RM1,500).  Hanum Ya’akub, Lim Siong Meng, Vasudevan Mani and Kalavathy Ramasamy (2013). Lactic acid bacteria down-regulating pro-inflammatory cytokines in DSS-induced colitis mice. The 2ndInternational Postgraduate Conference on Pharmaceutical Science (iPoPS 2013), Faculty of Pharmacy, UiTM Puncak Alam, Malaysia.
  2. Gold Medal. Mohd Fareez Ismail, Lim Siong Meng, Kalavathy Ramasamy, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) Capspro: Thermo- and pH-responsive microspheres with enhanced probiotic stability and targeted delivery in human gut. Invention, Innovation and Design Expo 2013, DATC, UiTM Shah Alam.
  1. Best Poster Award (4thPlace).  Azidah Ali, Kalavathy Ramasamy, L. K. Teh, Vasudevan Mani, MZ Salleh, Abu Bakar Abdul Majeed (2012) The use of LC-MS QTOF-based metabolomics to define the potential probiotic against colorectal cancer xenograft in the mouse. The 4thAustralasian Metabolomics Symposium and Workshop 2012, UiTM Puncak Alam.

Contact us

Dr. Gurmeet Kaur A/P Surindar Singh
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: +603 3258 4751

Address:
Brain Research Laboratory,
Level 7 – FF3 Building
Faculty of Pharmacy
UiTM Puncak Alam Campus
42300 Bandar Puncak Alam
Selangor. MALAYSIA.