Collaborative Drug Discovery Research (CDDR) Group

Main Focus of Current Research Projects

  • Probiotic and prebiotics as functional food (anti-cancer and neuroprotection)
  • Anticancer agents and underlying mechanisms (pro-apoptosis and anti-angiogenesis)
  • Microbial metabolites as neuroprotective agents
  • Pharmacoeconomics of antifungal agents
  • Diabetic self-care management programme

 

Organization Chart

* Link to Personal Website:

 

Contact

Assoc. Prof. Dr. Kalavathy Ramasamy
E-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: +60332584692 (Office)

Address:
CDDR Lab
Level 7 - FF3 Building
Faculty of Pharmacy
UiTM Puncak Alam Campus
42300 Bandar Puncak Alam

Postgraduate Students (Main/ Co-Supervision)

No.

Postgraduate Students

Degree

Institutions

Year Enrolled

Year End

1

Sherina Kamal

PhD

UiTM

2010

2014

2

Caroline Marajan

PhD

UiTM

2010

2014

3

Ainon Zahariah Samsudin

PhD

UiTM

2010

2015

4

Shirley Tang Gee Hoon

PhD

UPM

2012

2015

5

Wong Yuet Yen

PhD

USM

2014

2017

6

Azidah Ali

MSc

UiTM

2010

2014

7

Nor Nadia Ban

MSc

UiTM

2010

2014

8

Hanum Yaakub

MSc

UiTM

2010

2014

9

Fatimah Bebe

MSc

UiTM

2010

2015

10

Siti Munirah Jaafar

MSc

UiTM

2011

2014

11

Siti Norshazwani Wahab

MSc

UiTM

2011

2014

12

Siti Aisyah Sayadi

MSc

UiTM

2011

2014

13

Nor Amalina Ahmad

MSc

UiTM

2012

2014

14

Dayana Sazereen Bt Mohd Hasni

MSc

UiTM

2012

2014

15

Nur Syamimi Mohd Azahan

MSc

UiTM

2013

2015

16

Muhamad Khalil Bin Jamian

MSc

UiTM

2013

2015

17

Muhammad Zaki Ramli

MSc

UiTM

2013

2015

18

Muhammad Fareez Ismail

MSc

UiTM

2013

2015

19

Fatin Nadia Bt Masron

MSc

UiTM

2014

2016

20

Muhamad Zaki Bin Zakaria

MSc

UiTM

2014

2016

21

Suhana Bt Ahmad

MSc

UiTM

2014

2016

UiTM

On-going Research Grants (Principal Investigator/ Co-Researcher)

No.

Research Project

Source

Begin Year

End Year

 

Principal Investigator

1

Gut Hormones and Anti-inflammatory Pathways in Probiotics-mediated Glycaemic Control and Improved Quality of Life

FRGS (MOHE)

2014

2017

2

VEGF signalling cascade underlying endophytic peptides orchestrated anti-angiogenecity

FRGS (MOHE)

2013

2015

3

Integrative systems biology in understanding the cellular and molecular mechanisms of locally derived feed supplements for poultry

LRGS (MOHE)

2012

2017

4

Discerning potential neuroprotective activity of VCO on B-amyloid induced SH-SY5Y cell

ERGS (MOHE)

2011

2013

5

Probiotics as a neuroceutical for Alzheimer’s Disease

e-Science(MOSTI)

2012

2013

6

Novel and smart pH-sensitive 5-FU-loaded hydrogels for targeted drug delivery against colon cancer

RIF (UiTM)

2012

2014

 

Co-researcher

1

AD blood biomarkers and pathway analysis in the human subject: an integrative-OMICS approach

LRGS (MOHE) 2012 2016

2

Mechanism of ciproxifan against cholinergic deficit-induced neuronal plasticity via brain-derived neurotophic factor (BDNF) signaling pathway

FRGS (MOHE)

2013

2016

3

Diabetes self-management education (DSME): a smart community-universities partnership programme.

KTP (MOHE) 2014 2016

4

Vesicular neurotransmitter transporter: Bioenergentics and regulation of D-serine transport

FRGS (MOHE)

2012

2015

5

Metagenomics and metabolomics analysis of human gut microbiota: Evaluation of the redisposing mechanisms and probiotic effects on obesity

FRGS (MOHE)

2012

2015

6

Intranasal route for Alzheimer’s treatment using novel biodegradable polymeric nanoparticles

ERGS (MOHE)

2012

2015

7

Ciproxifan, a Histamine H3 Antagonist as a Potential Therapeutic agent in Alzheimer’s Disease

e-Science (MOSTI)

2013

2015

8

Neuroprotective roles of mahanimbine,a carbazole alkaloid from Murrraya koenigii leaves

e-Science (MOSTI)

2012

2014

9

Exercise and probiotic on scopolamine-induced memory deficits in experimental animal models

RIF (UiTM)

2012

2014

 

Selected Publications (2012 – 2014)

2014

  1. Mookiah S, Sieo CC, Ramasamy K, Abdullah N, Ho YW. (2014) Effects of dietary prebiotics, probiotic and synbiotics on performance, caecal bacterial populations and caecal fermentation concentrations of broiler chickens. Journal of the Science of Food and Agriculture, 94(2), 341-348 (IF = 1.76/ ISI/ Q1)
  2. Mishra RK, Ramasamy K, Ahmad NA, Eshak Z, Majeed AB (2014) pH dependent poly[2-(methacryloyloxyethyl)trimetylammonium chloride-co-methacrylic acid]hydrogels for enhanced targeted delivery of 5-fluorouracil in colon cancer cells. Journal of Materials Science: Materials Medicine 25(4), 999-1012 (IF = 2.14/ ISI/ Q1)
  3. Ahmad A, Ramasamy K, Jaafar SM, Majeed AB, Mani V. (2014) Total isoflavones from soybean and tempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain. Food and Chemical Toxicology, 65, 120-128 (IF = 3.010/ ISI/ Q1)
  4. Sadia Sultan, Lin Sun, John W. Blunt, Anthony L.J. Cole, Murray H.G. Munro, Kalavathy Ramasamy, Jean-Frédéric F. Weber (2014) Evolving trends in the dereplication of natural product extracts. 3: further lasiodiplodins from Lasiodiplodia theobromae, an endophyte fromMapania kurzii. Tetrahedron Letters, 55(2), 453–455 (IF = 2.4/ ISI/ Q2)
  5. R K Mishra, K Ramasamy, S M Lim, M F Ismail and A B A Majeed (2014) Antimicrobial and in vitro would healing properties of novel clay based bionanocomposite films. Journal of Materials Science: Materials in Medicine, 25(8), 1925-1939 (IF=2.379/ ISI/ Q1)
  6. Pooja Rohilla, Aakash Deep, Manju Kamra, Balasubramanian Narasimhan, Kalavathy Ramasamy, Vasudevan Mani, Rakesh Kumar Mishra, Siong Meng Lim (2014) Synthesis, antimicrobial and anticancer evaluation of N’-(substituted benzylidene)-2-(benzo[d]oxazol-3(2H)-yl)aceto hydrazine derivatives. Drug Research, 64, doi: 10.1055/s-0034-1368720 (IF=0.559/ ISI/ Q3)
  7. Kumar, M., Narasimhan, B., Ramasamy, K., Mani, V., Mishra, R.K., Majeed, A.B.A (2014)Synthesis, antimicrobial and cytotoxic evaluation of 4-(1-aryl-5-halo-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulphonamides. Arabian Journal of Chemistry, http://dx.doi.org/10.1016/j.arabjc/2013.11.009 (IF = 2.266/ SCOPUS/ ISI/ Q3).
  8. Neoh CF, Daniell M, Chen SC-A, Stewart K, Kong DCM (2014) Clinical utility of caspofungin eye drops in fungal keratitis. International Journal of Antimicrobial Agents, In Press. IF = 4.415/ ISI/ Q1)
  9. Neoh CF, Snell GI, Levvey B, Kotsimbos T, Morrissey CO, Slavin MA, Stewart K, Kong DCM (2014) Lung transplant recipients receiving voriconazole and skin squamous cell carcinoma risk in Australia. Medical Journal of Australia, In Press. (IF = 2.85/ ISI/ Q2)
  10. Neoh CF, Kong DCM (2014). The cost-effectiveness of boceprevir for hepatitis C (Invited Review). Expert Review of Pharmacoeconomics & Outcomes Research, In Press. (IF = 1.67/ ISI)
  11. Neoh CF, Snell GI, Levvey B, Kotsimbos T, Morrissey CO, Slavin MA, Stewart K, Kong DCM. Antifungal prophylaxis in lung transplantation. International Journal of Antimicrobial Agents, in press. (IF = 4.415/ ISI/ Q1)

2013

  1. Nurul Aqmar M.N. Hazalin, Siong Meng Lim*, Anthony L.J. Cole, Abu Bakar A. Majeed and Kalavathy Ramasamy (2013) Apoptosis induced by desmethyl-lasiodiplodin is associated with upregulation of apoptotic genes and downregulation of monocyte chemotactic protein-3. Anti-Cancer Drugs, 24 (8), 852-861 (IF = 2.232/ SCOPUS/ ISI / *Joint First Authorship/ Q1)
  2. Mishra, R.K., Ramasamy, K., Ban, N.N., Majeed, A.B.A. (2013) Synthesis of poly[3-(methacryloylamino) propyl trimethylammonium chloride-co-methacrylic acid] copolymer hydrogels for controlled indomethacin delivery. Journal of Applied Polymer Science, 128 (5), 3365-3374 (IF = 1.395/ SCOPUS/ ISI/ Q2)
  3. Sufian, A.S., Ramasamy, K., Ahmat, N., Zakaria, Z.A., Yusof, M.I.M. (2013) Isolation and identification of antibacterial and cytotoxic compounds from the leaves of Muntingia calabura L.Journal of Ethnopharmacology, 146 (1), 198-204 (IF = 2.755/ SCOPUS/ ISI/ Q1)
  4. Darawi, M.N., Ai-Vyrn, C., Ramasamy, K., Hua, P.P.J., Pin, T.M., Kamaruzzaman, S.B., Majeed, A.B.A. (2013) Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms. BMC Medical Genetics, 14 (1), art. no. 27 (IF = 2.54/ SCOPUS/ ISI/ Q3)
  5. Saini, M., Kumar, P., Kumar, M., Ramasamy, K., Mani, V., Mishra, R.K., Majeed, A.B.A., and Narasimhan, B. (2013) Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N?-(substituted)-4-(butan-2-lideneamino)benzohydrazides. Arabian Journal of Chemistry,http://dx.doi.org/10.1016/j.arabjc.2013.05.010.(IF = 2.266/ SCOPUS/ ISI/ Q3)
  6. Kumar, M., Narasimhan, B., Kumar, P., Ramasamy, K., Mani, V., Mishra, R.K., Majeed, A.B.A. (2013) 4-(1-Aryl-5-chloro-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides: Synthesis, antimicrobial, anticancer evaluation and QSAR studies. Arabian Journal of Chemistry,http://dx.doi.org/10.1016/j.arabjc.2013.03.002(IF = 2.266/ SCOPUS/ ISI/ Q3)
  7. Vasudevan, M., Kalavathy, R., Aliya, A.,Wahab, S.N., Jaafar, S.M., Teh, L. K., Salleh.M.Z., Majeed A.B.A. (2013) Effects of the total alkaloidal extract of Murraya koenigii leaf on oxidative stress and cholinergic transmission in aged mice. Phytotherapy Research, 27 (1), 46-53 (IF = 2.068/ SCOPUS/ ISI/ Q2)
  8. Kumar, P., Narasimhan, B., Ramasamy, K., Vasudevan, M., Mishra, R. K., Majeed, A. B. A., Clercq, E. D., N'-(4-((substituted imino)methyl)benzylidene)-substituted benzohydrazides: synthesis, antimicrobial, antiviral, anticancer evaluation, and QSAR studies. Monatshefte fur Chemi, 144 (6), 825-849 (IF = 1.629/ SCOPUS/ISI/ Q2)
  9. Kumar, M., Ramasamy, K., Mani, V., Mishra, R.K., Majeed, A.B.A., Clercq, E.D., Narasimhan, B. (2013) Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulphonamides. Arabian Journal of Chemistry,http://dx.doi.org/10.1016/j.arabjc.2012.12.005(IF = 2.266/ SCOPUS/ ISI/ Q3)
  10. Kumar, H., Kumar, P., Narasimhan, B., Kalavathy, R., Vasudevan, M., Mishra, R.K., Majeed, A.B.A. (2013) Synthesis, in vitro antimicrobial, anticancer and QSAR studies of N-(substituted phenyl)-2/4-(1H-indol-3-ylazo)-benzamides. Medicinal Chemistry Research, 22 (4), 1957-1971 (IF = 1.612/ SCOPUS/ ISI/ Q3)
  11. Neoh CF, Slavin MA, Chen SC-A, Stewart K, Kong DCM (2013) Echinocandins in the treatment of candidaemia and invasive candidiasis (IC): clinical and economic perspectives. International Journal of Antimicrobial 43, 207-214 (IF = 4.415/ ISI/ Q1)
  12. Neoh CF, Snell GI, Levvey B, Kotsimbos T, Morrissey CO, Slavin MA, Stewart K, Kong DCM (2013) Pre-emptive prophylaxis with voriconazole in lung transplant recipients. Transplant Infectious Disease, 15(4), 344-353 (IF = 2.216/ ISI/ Q3)
  13. Neoh CF, Liew D, Slavin MA, Marriott D, Chen SC-A, Morrissey CO, Stewart K, Kong DCM (2013) Economic evaluation of micafungin versus liposomal amphotericin B (LAmB) for the treatment of invasive candidiasis. Mycoses, 56(5), 532-542 (IF = 2.247/ ISI/ Q2)
  14. Neoh CF, Liew D, Slavin MA, Marriott D, Chen SC-A, Morrissey CO, Stewart K, Kong DCM (2013) Economic evaluation of micafungin versus caspofungin for the treatment of invasive candidiasis. Internal Medicine Journal, 46(3), 668-677 (IF = 1.541/ ISI/ Q2)

2012

  1. K Ramasamy, NZA Rahman, SC Chin, NJ Alitheen, N Abdullah, HY Wan. (2012) Probiotic potential of lactic acid bacteria from fermented Malaysian food or milk products. International Journal of Food Science & Technology, 47 (10), 2175–2183 (IF = 1.259/ SCOPUS/ISI)
  2. Hazalin, N A, Ramasamy, K, Lim, S M, Cole, A L, Majeed, A B. (2012) Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest. Phytomedicine, 19 (7), 609-617 (IF = 3.268/ SCOPUS/ ISI/ Q1)
  3. Mishra, R. K., Ramasamy, K. and Majeed, A.B.A. (2012) pH-Responsive Poly(DMAPMA-co-HEMA)-Based Hydrogels for Prolonged Release of 5-Fluorouracil. Journal of Applied Polymer Science, 126 , E98-E107 (IF = 1.395/ SCOPUS/ ISI/ Q2)
  4. Vasudevan, M., K, Ramasamy, A. Aliya, P. Milind, A.A.S. Syed and B.A.M. Abu (2012) Protective effects of total alkaloidal extract from Murraya koenigii leaves on experimentally induced dementia. Food and Chemical Toxicology, 50, 1036-1044 (IF = 3.010/ SCOPUS/ ISI/ Q1)
  5. Sharma, S.K., P. Kumar, B. Narasimhan, K. Ramasamy, M. Vasudevan, R.K., Mishra and A.B.A. Majeed (2012) Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters. European Journal of Medicinal Chemistry, 48, 16-25 (IF = 3.499/ SCOPUS/ ISI/ Q1)
  6. Sigroha, S., P. Kumar, B. Narasimhan, K. Ramasamy, M. Vasudevan, R.K., Mishra and A.B.A. Majeed (2012) Design, synthesis, antimicrobial, anticancer evaluation and QSAR studies of 4-(substituted benzylidene-amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-ones. Medicinal Chemistry Research, 21 (11) , 3863-3875 (IF = 1.612/ SCOPUS/ ISI/ Q3)
  7. Neoh CF, Jacob J, Leung L, Li J, Stathopoulos A, Stewart K, Kong DCM (2012) Stability of extemporaneously prepared 0.5% caspofungin eye drops: a potential cost-saving exercise. Antimicrobial Agents Chemotherapy, 56(6), 3435-3437 (IF = 4.841/ ISI/ Q1)
  8. Neoh CF, Kong DCM, Slavin MA, Chen SC-A (2012) Pharmacological and host considerations surrounding dose selection and duration of therapy with echinocandins. Current Fungal Infection Reports, 6(2), 95-106 (SCOPUS/ Q3)

 

Selected Awards (2012 – 2014)

2014

  1. 2nd runner up (poster presentation). R. M. Zaki, K. Ramasamy and S. M. Lim (2014) RhoA targeting by Lactobacilli as strategy to interfere the critical link to major hallmark of Alzheimer’s disease. The 3rd International Postgraduate Conference on Pharmaceutical Science (iPoPS 2014), Faculty of Pharmacy, UiTM Puncak Alam, Malaysia
  2. Silver Medal. Nor Amalina Ahmad, Muhamad Fareez Ismail, Lim Siong Meng and Kalavathy Ramasamy (2014) AD-Caps: When gut-brain connects. Malaysia Technology Expo 2014, PWTC, Kuala Lumpur
  3. Silver medal. R. M. Zaki, Ismail M. Fareez, K. Ramasamy and S. M. Lim (2014) Stay healthy, stay Rho-buzz. Invention, Innovation and Design Expo 2014, DATC, UiTM Shah Alam
  4. Best poster presentation. I. M. Fareez, S. M. Lim, R. K. Mishra and K. Ramasamy. (2014) Lactobacillus plantarum load chitosan coated alginate-xanthan gum beads elicited pH and heat resistance. Pharmacology and Chemistry Colloquium 2014, Faculty of Pharmacy, UiTM Puncak Alam Campus, Selangor Darul Ehsan, Malaysia.

2013

  1. Bank Islam Malaysia special award. Nor Amalina Ahmad Alwi, Muhamad Fareez Ismail, Kalavathy Ramasamy, Lim Siong Meng, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) AD-Caps: When gut-brain connects. IIDEX13-SE Innovateur Wannabe!, Dewan Sri Budiman & Anjung Sri Budiman (Annex), UiTM Shah Alam.
  2. Best poster award. Nor Amalina Ahmad Alwi, Muhamad Fareez Ismail, Kalavathy Ramasamy, Lim Siong Meng, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) AD-Caps: When gut-brain connects. IIDEX13-SE Innovateur Wannabe!, Dewan Sri Budiman & Anjung Sri Budiman (Annex), UiTM Shah Alam.
  3. Category B (Champion). Nor Amalina Ahmad Alwi, Muhamad Fareez Ismail, Kalavathy Ramasamy, Lim Siong Meng, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) AD-Caps: When gut-brain connects. IIDEX13-SE Innovateur Wannabe!, Dewan Sri Budiman & Anjung Sri Budiman (Annex), UiTM Shah Alam.
  4. Best oral presentation award. Nor Amalina Ahmad, Lim Siong Meng, Vasudevan Mani, Abu Bakar Abdul Majeed and Kalavathy Ramasamy (2013) Lactobacillus probiotic-induced neuroprotection in transgenic mice with Alzheimer’s disease was mediated, in part, through cholinergic and antioxidative pathways. The 3rd International Symposium on Probiotics and Prebiotics: Microbiome, Gut-Brain Axis in Health and Disease - Mechanism, Function and Regulation, Sari Pan Pacific Hotel, Jakarta.
  5. Best poster presentation award. Hanum Ya’akub, Lim Siong Meng, Vasudevan Mani and Kalavathy Ramasamy (2013) Lactic acid bacteria down-regulating pro-inflammatory cytokines in DSS-induced colitis miceThe 2ndInternational Postgraduate Conference on Pharmaceutical Science (iPoPS 2013), Faculty of Pharmacy, UiTM Puncak Alam, Malaysia.
  6. Consolation Prize. UiTM Excellence Laboratory Award 2013.
  7. Gold Medal. Mohd Fareez Ismail, Lim Siong Meng, Kalavathy Ramasamy, Rakesh Mishra, Vasudevan Mani and Abu Bakar Abdul Majeed (2013) Capspro: Thermo- and pH-responsive microspheres with enhanced probiotic stability and targeted delivery in human gut. Invention, Innovation and Design Expo 2013, DATC, UiTM Shah Alam.
  8. Vice-Chancellor's Commendation for Doctoral Thesis Excellence (Monash University, Australia)
  9. Staff Publication Award (Bronze) (UiTM, Penang)
  10. Innovation Platform (Bronze) (UiTM, Penang)

2012

  1. The University of Western Sydney School of Medicine Award for the best student presentation at the 2012 Australian Society for Medical Research NSW Annual Scientific Meeting, Australian Technology Park, Redfern, Australia.
  2. Second runner up of the St George Clinical School Postgraduate 2012 Three Minute Thesis Competition.
  3. Best Poster Award (4th Place). Azidah Ali, Kalavathy Ramasamy, L. K. Teh, Vasudevan Mani, MZ Salleh, Abu Bakar Abdul Majeed (2012) The use of LC-MS QTOF-based metabolomics to define the potential probiotic against colorectal cancer xenograft in the mouseThe 4thAustralasian Metabolomics Symposium and Workshop 2012, UiTM Puncak Alam.
  4. Best Poster. M. Saminathanm C.C Sieo, R. Kalavathy, N. Abdullah and Y.W. Ho. (2012) Effects of prebiotic oligosaccharides on growth kinetics of probiotic Lactobacillus strains in vitro and growth performance and caecal bacterial populations of broiler chickens inThe 33rdMSAP Annual Conference, 4-7 June 2012, Langkawi, Malaysia.
  5. Best Poster. M. Saminathan C.C Sieo, R. Kalavathy, N. Abdullah and Y.W. Ho. (2012) Effects of prebiotcs and synbiotics on growth performance and serum lipid concentrations ofThe 5th International Conference of Animal Nutrition, 24-26 April 2012, Melaka, Malaysia.
  6. Postgraduate Publication Award (Monash University, Australia)
  7. Staff Publication Award (Bronze) (UiTM, Penang)