Research on Affinity, Safety and Efficacy Studies (OASES)

About us:

The main focus of OASES is in areas of pharmacology and neurosciences. This research group is comprised of individuals who have interacted informally and collaborated on research involving range of aspect of toxicology and pharmacology.

The OASES group is headed by Prof Dr. Aishah Adam who trained in Biochemical Toxicology before joining academic in 1985. She is currently the Dean of Faculty of Pharmacy, advisor editor of Malaysian Journal of Pharmacy and Asia Pacific Journal of Pharmacology.

Other members include:

  1. Assoc. Prof. Dr Kazi Ahsan Jamil (Faculty of Dentistry, UiTM Shah Alam)
  2. Dr Mizaton Hazizul Hasan (Faculty of Pharmacy, UiTM Puncak Alam)
  3. Dr Nur Suraya Adina Suratman (Faculty of Pharmacy, UiTM Puncak Alam)
  4. Dr Aida Azlina Ali (Faculty of Pharmacy, UiTM Puncak Alam)
  5. Pn Maziana Mahamood (Faculty of Pharmacy, UiTM Puncak Alam) 

OASES use in vitro and in vivo models to investigate the effects of drugs and natural compounds on body system. Since 2012, group members have obtained significant research funding as project leaders, amounting to RM 877 000.00. Members are also actively collaborating with researchers from other groups.

On-going Research Grants:

No

Title of Research

Status of Researcher

Source of Funding

 1

Research of Affinity, Safety, Efficacy Studies (OASES)

Project Leader

REI Tier 5

Mechanistic Studies On Glucose Uptake And Insulin Secretion Activities by Pure Compounds of Octomeles Sumatrana (DATISCACEAE)

Project Leader

FRGS 2013

 

The In Vivo Effects Of 3,4,10-Trimethoxystilbene On Hepatocellular Carcinoma In SCID Mouse Xenograft Model

Project Leader

ERGS 2013

The in vivo effects of 3,4,10-trimethoxystilbene on hepatocellular carcinoma in scid mouse xenograft model part 2

Project Leader

UiTM/PSI 2013

The in vivo effects of 3,4,10-trimethoxystilbene on hepatocellular carcinoma in scid mouse xenograft model part 3

Project Leader

UiTM/ CIFI 2013

Molecular Mechanisms for Improvement of Cognitive Parameters and Ammelioration of ?-Amyloid Production in Senescence-Accelerated Mice by Fraction 7 of Polygonum minus(Polygonaceae)

Project Leader

FRGS 2012

Molecular Mechanisms for Improvement of Cognitive Parameters and Ammelioration of ?-Amyloid Production in Senescence-Accelerated Mice by Fraction 7 of Polygonum minus(Polygonaceae) part 2

Project Leader

UiTM/PSI 2013

Evaluation of Wound Healing Activity of Hibiscus rosa-sinensis Using Incision Wound Model.

Project Leader

RIF 2012

Mechanism pathway of Hibiscus rosa sinensis leaves extract fractions on antidiabetic properties in Alloxan-induced diabetic rats.

Project Leader

RAGS 2012

10 

Immunomodulatory effect of Myrmecodia platytyrea

Project Leader

RIF 2012

11 

Mechanism of folate metabolism: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in Malaysian mothers with Down syndrome children

Project Leader

RAGS 2012

12 

Elucidation of banana soft pith (Musa sp.) antiproliferative activity and identification of it’s active compounds

Co-Researcher

RAGS 2012

13 

Identifying the key gene (s) of post-surgical pain for new drug discovery using gabapentin.                                                                                                         

Co-Researcher

RAGS 2013

14 

Molecular mechanism of dental amalgam toxicity in rat central nervous system

Co-Researcher

RAGS 2013

15 

Molecular Mechanism of Temporomandibular Joint Disorder (TMD)

Co-Researcher

RAGS 2012

16 

Oral Health Status Of Inmates In A Malaysian Prison

Co-Researcher

RIF 2012

17 

Molecular Mechanism of underlying therapeutic function of Probiotic drink in gingivitis

Co-Researcher

RIF 2012

18 

Localization of Transient Receptor Potential Ankyrin 1 (TRPA1) in the Periodontal Ligament of Rat incisor

Co-Researcher

RIF 2012 

 

Selected Publications:

  1. El Hassane Anouar, Zuhra Bashir Lkhalifa Al trabolsy, Nur Shahidatul Shida Zakaria, Manar Zulkeflee, Mizaton Hazizul Hasan, Maisarah Mohd Zin, Rohaya Ahmad, Sadia Sultan, Jean-Frédéric F. Weber (2014). Antioxidant activity, NMR, X-ray, ECD and UV/visible spectra of (+)-terrein: Experimental and theoretical approaches. Journal of Molecular Structure 1060: 102–110 ISI indexed (IF=1.404)
  2. Mohd Shahezwan Abd Wahab, Aida Azlina Ali, Hanis Hanum Zulkifly and Noorizan Abd Aziz, “The need for evidence-based complementary and alternative medicine (CAM) information in Malaysian pharmacy curricula based on pharmacy students’ attitudes and perceptions towards CAM”, Currents in Pharmacy Teaching and Learning, 2014, 6(1): 114-121. SCOPUS Indexed.
  3. El Hassane Anouar,Salwa Raweh, Imene Bayach, Muhammad Taha,Mohd Syukri Baharudin, Florent Di Meo, Mizaton Hazizul Hasan, Aishah Adam,Nor Hadiani Ismail,Jean-Fre´de´ric F. Weber, Patrick Trouillas. Antioxidant properties of phenolic Schiff bases: structure–activity relationship and mechanism of action.J Comput Aided Mol Des.DOI 10.1007/s10822-013-9692-0. Impact Factor 2012: 3.172. Accepted manuscript.
  4. N. H. Mohd-Radzman, W. I. W. Ismail, S. S. Jaapar, Z. Adam, A. Adam. Stevioside from Stevia rebaudiana Bertoni Increases Insulin Sensitivity in 3T3-L1 Adipocytes. Evidence-Based Complementary and Alternative Medicine 2013, Article ID 938081, 9 pages. http://dx.doi.org/10.1155/2013/938081. Thomson Reuters (ISI) Impact Factor 2012: 1.722. Accepted manuscript.
  5. M. Abd Elgadir, Aisha Adam and Mohamed E. S. Mirghani. 2012. Fish Gelatin and its Applications in Selected Pharmaceutical Aspects as Alternative Source to Pork Gelatin, Review. International Journal of Food, Agriculture & Environment (JFAE). Accepted manuscript.  IF: 0.425.  ISI Web of Knowledge
  6. M. Abd Elgadir, M.S. Mohamed, Aishah Adam.  Carica Papaya as a potential medicinal plant and its utilization in selected pharmaceutical applications, Review.  International Journal of Pharmacy and Pharmaceutical Sciences.  Accepted manuscript.  IF 0.38 (SCImago, SJR 2010), 4.5 (ICV 2010).  Scorpus
  7. Nabilatul Hani Mohd-Radzman, W. I. W. Ismail, Zainah Adam, Siti Safura Jaapar, and Aishah Adam. Potential Roles of Stevia rebaudiana Bertoni in Abrogating Insulin Resistance and Diabetes: A Review. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 718049, 10 pages. 2013 Thomson Reuters (ISI) Impact Factor 2012: 1.722. http://dx.doi.org/10.1155/2013/718049
  8. RK Wesam, AN Ghanya, HH Mizaton, M Ilham, A Aishah. Assessment of genotoxicity and cytotoxicity of standardized aqueous extract from leaves of Erythroxylum cuneatum in human HepG2 and WRL68 cells line. Asian Pacific Journal of Tropical Medicine, 811-816, 2013. Thomson Reuters (ISI) Impact Factor 2012: 0.502
  9. Mohamed Abd Elgadir Saeed, Aishah Adam. An in vitro evaluation of films prepared from gelatin – Carica papaya methanolic extract for wound healing. International Journal of Drug Delivery, 5 (2), 2013. Scopus Impact Factor. 1.02. http://www.arjournals.org/index.php/ijdd/article/view/899
  10. Khaled.A.A.Alkadi, Aishah Adam, Muhammad Taha, Mizaton Hazizul Hasan an Syed Adnan Ali Shah.  Antiplatlet aggregation activity of 5-Hydroxyflavone, 2’-Hydraxyflavone, Paenol and bergenis isolated from stem bark of Garcinia malaccensis in human whole blood. Oriental Journal of Chemistry, 29 (3), 2013.  Thomson Reuters (ISI), Scopus H Index 6. http://www.orientjchem.org/?p=262
  11. Aida Azlina Ali, Syafinaz Mohd Yusoff, Suhaidah Mohd Jofrry, Mohd Shahezwan Abd Wahab, 2013. Effectiveness of a Drug Information Service (DIS) Awareness Programme and Characteristics of Inquiries at DIS Unit in Malaysian Public Hospital. Archive of Pharmacy Practice, 4(1): 9-14.
  12. C.M. John, R. Ramasamy, G. Al Naqeeb, A.H.D. Al-Nuaimi and A. Adam.  Nicotinamide Supplementation Protects Gestational Diabetic Rats by Reducing Oxidative Stress and Enhancing Immune Responses.  Current Medicinal Chemistry, 2012, 19, 5181-5186. Impact Factor: 4.859.  ISI Web of Knowledge.
  13. Kazi JA. Nocistatin and nociceptin modulate c-Fos expression in the mice thalamus. Neurol Sci. 2012 Jan 13. [Epub ahead of print] . December 2012, Volume 33, Issue 6, pp 1233-1237  (ISI: Impact Factor 1.50).
  14. Mohd Aidil Azahar, Ghanya Al-Naqeb, Mizaton Hasan, Aishah Adam. Hypoglycemic effect of Octomeles sumatrana aqueous extract in streptozotocin-induced diabetic rats and its molecular mechanisms. Asian Pacific Journal of Tropical Medicine, 2012 875-881. Thomson Reuters (ISI) 5-Year Impact Factor: 0.403.
  15. Siti Rohani Saleh, Mizaton Hazizul Hasan, Md Ikram Mohd Said, Mohd Ilham Adenan and Aishah Adam.  Antioxidant, anti-inflammatory and antinociceptive activities of Mitragyna speciosa and Erythroxylum cuneatum. IEEE Symposium on Humanities, Science and Engineering Research, 2012, 1087-1091. 
  16. G Narasimhulu, A. Adam, T Lavanya, SR Reddy S, KS Reddy.  Protective effect of Pimpinella Tirupatiensis Bal. and Subr. An endangered medicinal plant of Tirumala Hills against streptozotocin generated oxidative stress induced diabetic rats.  International Research Journal of Pharmacy (IRJP) 2012, 3(7), 308-314.  Scopus.
  17. G. Narasimhilu, T. Lavanya, S. Rajeswara Reddy, K. Mallikarjuna, P. Visweswara Rao, Aishah Adam, K. Sathyavelu Reddy.  Pharmacological effects of Pimpinella tirupatiensis on altered urea cycle and liver function markers in diabetic rats.  International Journal of Pharmacology 8(5): 382-388, 2012H Index: 9.  ISI Web of Knowledge
  18. Narasimhulu Ganapathi ,Aishah Adam, Kesireddy Sathyavellu Reddy, Mohammed Arifullah.  A Review of Recent Research of Medicinal Properties of Pimpinella tirupatiensis Bal. & Subr. An Endemic to Tirumala Hills of Eastern Ghats, India.  Journal of Pharmacy Research, 5(8), 4233-4235, 2012.
  19. Hamsar, M. N. & Mizaton, H. H. (2012). Potential of Ant-Nest Plants as an Alternative Cancer Treatment. Journal of Pharmacy Research, 5(6): 3063-3066.
  20. Hazizul Hasan, M, Sunggip, C, Mansor, M, Adam, A. In vitro antioxidant activities: Comparative analysis of the Octomeles sumatrana, Eugenia polyantha and Intsia palembanica extracts. Free Radical Research, 43 (1), S27-97. ISI indexed (IF=3.279) 

Selected Awards:

  1. Gold Medal (Staff: Innovations Category). Norhayati Abu Samah, Khuriah Abdul Hamid, Rozaini Mohd Zohdi, Aida Azlina Ali (2013) Trigo Derm Moisturizer. Inventions, Innovations and Design Exhibition (IIDEX 2013), UiTM
  2. Silver Medal (Staff: Innovations Category). Nur Suraya Adina Suratman, Mizaton Hazizul Hasan, Maziana Mahamood, Aida Azlina and Aishah Adam (2013) Ulcer-OFF. Inventions, Innovations and Design Exhibition (IIDEX 2013), UiTM
  3. Silver Medal (Postgraduate: Innovations Category). Cini Matthews John, Farhana Abdul Rahman, Mizaton Hazizul Hasan, Aishah Adam (2013) Cassia Gold. Inventions, Innovations and Design Exhibition (IIDEX 2013), UiTM
  4. Bronze Medal (Postgraduate: Innovations Category). Siti Rohani Saleh, Syed Mohd Nuzul Ikwan Syed Ibrahim, Mizaton Hazizul Hasan, Maziana Mahamood and Aishah Adam (2013) Cool-X Roll-On. Inventions, Innovations and Design Exhibition (IIDEX 2013), UiTM 

Contact Us:

Pharmacology-Toxicology Research Lab

Level 6, FF3,

Faculty of Pharmacy,

UiTM Puncak Alam

42300 Bandar Puncak Alam,

Selangor, MALAYSIA.

 

Tel : 03-32584646

Fax: 03-32584602

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.