Assoc. Prof. Dr Kalavathy Ramasamy and team had isolated a unique probiotic lactic acid bacterial (LAB) strain, Lactobacillus plantarum LAB12, with excellent cholesterol assimilation properties in vitro. Instead of using conventional methods of quantification, they had demonstrated for the first time that both qualitative and quantitative evaluations of cholesterol assimilation by probiotics could be effectively performed by confocal microscopy. Their effort was made possible by a sterol-binding fluorescent probe that allowed exogenous cholesterol to be fluorescently tagged. Assimilation of cholesterol that fluoresce by LAB12 could then be visualised through a confocal microscope. For more details, please read https://doi.org/10.1007/s00216-018-1544-2
Prof. Dr Kalavathy Ramasamy
Dr Lim Siong Meng
Dr Lim Fei Tieng
Rohawi Nur Syakila
Collaborative Drug Discovery Research (CDDR) Group,
Faculty of Pharmacy,
Universiti Teknologi MARA (UiTM) Selangor,
Puncak Alam Campus, Branch, Malaysia
Alzheimer’s Disease (AD), which is also simply known as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, inability to manage selfcare, and behavioural issues. There are no treatments to stop or reverse its progression, though some may temporarily improve symptoms. This has been the focus of a research team lead by Professor Dato' Dr. Abu Bakar Abdul Majeed, where they are looking for potential therapeutic agents against AD, for instance by using Ciproxifan, a Histamine H3 antagonist.
Prof Dato' Dr. Abu Bakar Abdul Majeed
Head, Brain Degeneration and Therapeutics Group, Faculty of Pharmacy,
UiTM Puncak Alam, Selangor
The prevalence of Alzheimer's disease (AD) has increased with the fast growing of aging population, thereby posing great challenges to provision of care for AD patients.