Alzheimer’s Disease (AD), which is also simply known as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, inability to manage selfcare, and behavioural issues. There are no treatments to stop or reverse its progression, though some may temporarily improve symptoms. This has been the focus of a research team lead by Professor Dato' Dr. Abu Bakar Abdul Majeed, where they are looking for potential therapeutic agents against AD, for instance by using Ciproxifan, a Histamine H3 antagonist.
Prof Dato' Dr. Abu Bakar Abdul Majeed
Head, Brain Degeneration and Therapeutics Group, Faculty of Pharmacy,
UiTM Puncak Alam, Selangor